小剂量螺内酯对急性心肌梗死患者左心室重构的影响被引量：3

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摘要目的探讨小剂量螺内酯对急性心肌梗死患者左心室重构的影响。方法 80例急性心肌梗死患者随机分为螺内酯组和对照组各40例,对照组按临床路径给予再灌注和/或常规药物治疗,螺内酯组在对照组治疗的基础上加用小剂量螺内酯20mg/d,观察心肌梗死后1天、7天静脉血BNP水平,1天、7天和3个月时超声心动图LVDD及LVEF的变化。结果心肌梗死后7天螺内酯组BNP水平较对照组降低(P<0.01);心肌梗死后1天、7天两组LVDD、LVEF均无明显差异(P>0.05),3个月时螺内酯组LVDD扩大程度较对照组明显(P<0.01);心肌梗死后3个月两组LVEF较前均有不同程度的下降,但螺内酯组高于对照组(P<0.01)。结论小剂量螺内酯可以明显降低急性心肌梗死患者急性期BNP水平,并改善远期(3个月)左心室重构和心功能。

作者薛迎生卢先本许莎莎江建军唐礼江

机构地区台州医院

出处《浙江实用医学》 2010年第6期419-421,共3页 Zhejiang Practical Medicine

关键词螺内酯急性心肌梗死 B型钠尿肽左心室重构

分类号 R542.22 [医药卫生—心血管疾病]

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