藿香正气不同剂型产品药效比较实验

Comparative study on efficacy of different formulations of Huoxiang Zhengqi products

目的比较藿香正气不同剂型产品以各自临床用量的相同倍数给药,其止泻、止吐及解痉作用。方法采用番泻叶致小鼠腹泻实验模型,观察单次量ig给药后,小鼠的腹泻潜伏期、腹泻率、腹泻级数及腹泻指数;采用硫酸铜致家鸽呕吐实验模型,观察单次量ig给药后,家鸽的呕吐潜伏期、呕吐次数及呕吐持续时间;采用甲硫酸新斯的明致小鼠小肠痉挛实验模型,观察单次量ig给药后,炭末推进百分率。结果藿香正气不同剂型产品均有不同程度的止泻作用;藿香正气胶囊、藿香正气软胶囊均有明显的止吐作用;藿香正气胶囊、藿香正气软胶囊、藿香正气滴丸均有明显的解痉作用。结论藿香正气胶囊作用最强,藿香正气软胶囊次之,不同厂家的产品作用强度有差异。

【Abstract】 Objective To compare the antidiarrheal,antiemetic and antispasmodic effects of different formulations of Huoxiang Zhengqi.Methods The diarrhea model of mice was induced by senna,and the incubation period,diarrhea rate,diarrhea progression and diarrhea index of mice were observed.The vomiting model of pigeon was induced by copper sulfate,and the incubation period,vomiting time and duration were observed.The mice model of small intestinal spasm was induced by neostigmine metilsulfate,and the percentage of carbon was observed.Results Huoxiang Zhengqi samples of different forms had varying degrees of antidiarrheal effects;Huoxiang Zhengqi Capsule,soft capsule had significant antiemetic effects;Huoxiang Zhengqi Capsules,soft capsules,and dripping pills had obvious spasmolysis.Conclusion The effect of Huoxiang Zhengqi Capsules is strongest,soft capsule is stronger than other formulations,and the potency is different among different manufacturers.