白细胞计数对急性心肌梗死患者静脉溶栓疗效的影响

The Influence of White Blood Cell Counts on Efficacy of Intravenous Thrombolysis in Patients with Acute Myocardial Infarction

目的:探讨白细胞计数对急性心肌梗死(AMI)患者静脉溶栓疗效的影响。方法:连续入选51例具备溶栓适应证的AMI患者,男32例,女19例,分为两组:白细胞计数升高组(A组):27例;白细胞计数正常组(B组):24例。所有患者均于3～6h内行尿激酶溶栓治疗,观察两组患者的梗死相关血管再通率、出血并发症发生率、24h病死率和出院存活率。结果:两组患者的梗死相关血管再通率、出血并发症发生率、出院存活率差异无统计学意义(P>0.05),但A组的24小时病死率显著升高(P<0.05)。结论:白细胞计数升高提示AMI尿激酶静脉溶栓预后不良。

Objective：The study was designed to observe the influence of white blood cell counts on efficacy of intravenous thrombolysis in patients with acute myocardial infarction（AMI）. Methods：51 patients with AMI adapted to thrombolysis were enrolled. There were 32 males and 19 females. They were divided into two groups according to white blood cell counts： increased white blood cell counts group（A group） and normal white blood cell counts group（B group）. All patients underwent intravenous thrombolysis （streptokinase） during 3-6 hours after onset of AMI, and the reperfusion rates of infarct-related artery, rate of out-patient survival, incidence of haemorrhagic complications as well as the 24 hours mortality of two groups were compared.Results：There were no statistic differences between the repcrfusion rates of infarct-related artery, rates of out-patient survival and incidences of haemorrhagic complications of two groups, but the 24 hours mortality of A group was higher than that of B group.Conclusions：Higher white blood cell counts may exert adverse influence on efficacy ofintravenous thrombolysis in AMI patients.