依达拉奉对脑出血患者血清肿瘤坏死因子-α的影响

Effects of Edaravone on Serum Tumor Necrosis Factor-α in Patients with Cerebral Hemorrhage

目的:探讨依达拉奉对脑出血患者血清中肿瘤坏死因子-α(TNF-α)的影响。方法:选择84例脑出血患者,随机分为对照组(常规治疗)和依达拉奉组(依达拉奉+常规治疗,生理盐水100ml加入依达拉奉30mg,2次/日,连续14天静脉点滴),检测治疗前和治疗后患者血清中TNF-α浓度的变化,比较两组的疗效。结果:治疗后依达拉奉组血清中TNF-α的浓度(6.1±1.2)ng/L较对照组(10.2±3.1 0)ng/L显著下降(P<0.01),依达拉奉组总有效率85.71%,对照组57.14%,两者差异有统计学意义(P<0.01)。结论:依达拉奉对出血后脑组织具有保护作用,其机制可能与抑制TNF-α的活性有关。

Objective：To explore the effects of edaravone on serum tumor necrosis factor-α （TNF-α） in patients with cerebral hemorrhage,and observe the protective effect and possible mechanism of edaravone on hemorrhagic brain tissue.Methods：84 patients with cerebral hemorrhage were randomly divided into control group （conventional treatment） and the edaravone group （conventional treatmant＋edar avone,saline 100 to join edaravone 30mg,2 times/day for 14 consecutive days of intravenous）,detection serum tumor necrosis factor-α （TNF-α） concentration changes in patients and the efficacy of the two groups before and after treatment.Results：Edaravone group after treatment of serum TNF-α concentration （6.1 ±1.2）ng/L compared with the control group （ 10.2±3.10）ng/L decreased significantly （P〈0.01）.The total efficiency wsa 85.71% in edaravone group and 57.14% in the control group,difference was statistically significant （P〈0.01）.Conclusion：The edaravone has a protective effect on hemorrhagic brain tissue,the mechanism may be related to inhibiting the activity of TNF-α.