摘要
目的:研究血清MMP-9、TIMP-1和IL-6及hs-CRP水平在哮喘患儿治疗前后的变化及临床意义。方法:对67例哮喘患儿血清MMP-9、TIMP-1和IL-6及hs-CRP水平采用酶联免疫吸附试验(ELISA)法和散射比浊法进行检测,并与38名正常健康儿进行比较。结果:血清MMP-9、TIMP-1和IL-6及hs-CRP水平在哮喘患儿发作期和缓解期均显著地高于正常儿(P<0.01),且发作期又明显高于缓解期(P<0.01)。结论:联合检测血清MMP-9、TIMP-1和IL-6及hs-CRP水平的变化对哮喘患儿临床诊断和治疗具有一定的价值。
Objective：To study the change and clinical significance of serum MMP-9, TIMP-1, IL-6 and hs-CRP levels in patients with asthma. Methods：Serum MMP-9, TIMP-I, IL-6 and hs-CRP levels were measured in 67 patients with asthma,of whom 35 cases were in acute attack （A group） and 32 cases in the remmision period （B group） and 38 controls （C group）.Results：Serum MMP-9, TIMP-1, IL-6 and hs-CRP levels were significant higher in group A and B than those in group C （P〈0.01）.Which were higher in group A than those in group B （P〈0.01）. Conclusion：Detection of serum MMP-9, TIMP-1, IL-6 and hs-CRP levels is of a certain significance for guiding the clinical diagnosis and treatment in patients with asthma.
出处
《中国医药导刊》
2010年第12期2131-2132,共2页
Chinese Journal of Medicinal Guide
