米非司酮和左炔诺孕酮紧急避孕效果比较

Comparison of effects of mifepristone and levonorgestrel on emergency contraception

目的:比较米非司酮和左炔诺孕酮两种紧急避孕药物的避孕效果。方法:对206例无保护性生活后72 h内要求紧急避孕就诊的病例进行观察和分析。随机分为两组,组1:136例,单次口服米非司酮25 mg。组2:70例,口服左炔诺孕酮0.75 mg,12 h重复1片。结果:组1妊娠2例,失败率1.47%,避孕有效率84.10%,副反应率7.53%;组2妊娠3例,失败率4.29%,避孕有效率61.34%,副反应率17.14%。结论:两种药物都是有效的紧急避孕药物,米非司酮用于紧急避孕的效果优于左炔诺孕酮。

Objective： To compare the effects of mifepristone and levonorgestrel on emergency contraception.Methods： 206 patients with no protective sex required emergency contraception within 72 h were randomly divided into group1（n=136） and group 2（n=70）.In group 1,single oral mifepristone 25 mg;in group 2,oral levonorgestrel 0.75 mg and once more 0.75 mg after 12 h.Results： There were two cases of pregnancy in group 1 and three cases of pregnancy in group 2,the rate of failure was 1.47% in group 1 and 4.29% in group 2,the rate of effective contraception was 84.10% in group 1 and 61.34% in group 2,the rate of side reaction was 7.53% in group 1 and 17.14% in group 2.Conclusion： Both mifepristone and levonorgestrel are effective emergency contraceptives,but mifepristone for emergency contraception is better than levonorgestrel.