聚乙二醇干扰素α-2b治疗儿童慢性乙型肝炎的临床观察

Effect of pegylated interferon α-2b on children with HBeAg positive chronic hepatitis B

目的:观察聚乙二醇干扰素α-2b(佩乐能)治疗HBeAg阳性儿童慢性乙型肝炎疗效。方法:选择HBsAg、HBeAg、HBV-DNA均阳性的慢性乙型肝炎儿童13例,予聚乙二醇干扰素α-2b 1.5μg.kg-1,1周1次,疗程48周,观察患者肝功能、HBV-M、HBV-DNA变化及不良反应。结果:48周疗程结束时ALT复常率为92.3%,HBeAg血清学转换率及HBV-DNA转阴率分别为53.8%和69.2%。结论:聚乙二醇干扰素α-2b是治疗小儿慢性乙型肝炎的有效药物。

Objective： To study the effect of pegylated interferon α-2b on children with HBeAg positive chronic hepatitis B.Methods： 13 children with HBsAg,HBeAg,HBV-DNA positive chronic hepatitis B received pegylated interferon α-2b,one time a week,for 48 weeks.Results： At the end of treatment,the normalization of liver function was 92.3%.HBeAg seroconversion was 53.8% while the negative conversion ratio of HBV-DNA was 69.2%.Conclusion： Pegylated interferon α-2b is effective for children with HBeAg positive chronic hepatitis B.