婴幼儿肺炎肿瘤坏死因子α、一氧化氮及心肌酶的相关性

Study of tumor necrosis factor α、nitric oxide and enzyme in infantile pneumonia

目的 探讨肿瘤坏死因子α(TNFα)、一氧化氮(NO)在婴幼儿肺炎及肺炎并心力衰竭中的作用。方法 采用高效液相色谱技术等方法测定60例婴幼儿肺炎及30例健康对照儿童外周血TNFα、NO及肌酸激酶同功酶(CK-MB)。结果 肺炎组与对照组比较,TNFα、NO、CK-MB均显著增高。心衰组与肺炎组比较,仅TNFα、CK-MB增高有显著性差异。TNFα与CK-MB呈高度正相关。结论 TNFα、NO造成婴幼儿肺炎时心肌细胞的损伤,参与了心力衰竭的发生。

Objective To study the role of tumor necrosis factor α(TNFα)、nitric oxide(NO)in infantile pneumonia and pneumonia complicated heart failure. Methods We measured the levels of TNFα、NO and creatine kinase isoenzyme(CK MB) in 60 infant with pneumonia or pneumonia complicated heart failure,also in 30 healthy controls. Results The levels of TNFα,NO and CK MB were obviously increased in pneumonia group compared with normal group.Only TNFα and CK MB were significantly higher in group of heart failure than pneumonia group.A significantly positive correlation was obtained between TNFα and CK MB. Conclusion The results of the study suggest that NO and TNFα are associated with the myocardium injuries,development of infantile pneumonia.