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血管内皮细胞生长因子在急性肺损伤中的作用

Vascular endothelial growth factor in acute lung injury
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摘要 急性肺损伤(acute lurg injury,ALI)和急性呼吸窘迫综合征(acute respiratory distressyndrome,ARDS)的特征性病理改变为肺毛细血管通透性增高所致的肺水肿,血管内皮细胞生长因子能抗血管内皮细胞凋亡并增加血管通透性,可能在ALI和ARDS的病理过程中起到重要作用.现对血管内皮细胞生长因子在ALI中的作用进行综述,旨在为ALI和ARDS的治疗提供新的思路. Increased permeability and interstitial pulmonary edema are prominent features of acute lung injury (ALI)/acute respiratory distress syndrome(ARDS).Vascular endothelial cell growth factor(VEGF) has been identified by its properties to increase permeability and act as a cellular growth factor, thus it is a potential key role in the pathogenesis of ALI/ARDS. Understanding the role of VEGF in this disease process is crucial for developing new therapeutic strategies for ALI/ARDS.
作者 张曌 张诗海
出处 《国际麻醉学与复苏杂志》 CAS 2010年第6期532-534,共3页 International Journal of Anesthesiology and Resuscitation
关键词 血管内皮细胞生长因子 急性肺损伤 急性呼吸窘迫综合征 Vascular endothelial growth factor Acute lung injury Acute respiratory distresssyndrome
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