银杏达莫、黄芪注射液对原发性肾病综合征患者免疫及高凝状态的影响

Effect of Ginkgo-dipyridamole Injection and Radix Astragali Injection on Immune Globulin and Hypercoagulabale State in Primary Nephrotic Syndrome

目的探讨联用银杏达莫、黄芪注射液对原发性肾病综合征(PNS)患者免疫、高凝状态的影响,以及疗效观察。方法 PNS患者随机分为两组:在使用足量激素、常规治疗基础上,治疗组联用银杏达莫、黄芪注射液,每日一次静滴;对照组应用复方丹参注射液,每日一次静滴。2周为一个疗程,间隔2周后继续静滴,共3个疗程。分别于用药前和用药3个月后观察PT、APTT、FDP,IgG、IgA、IgM及补体C3、C4等指标的变化。结果 3个月后,治疗组在改善免疫力及高凝状态上明显优于对照组(P<0.05),总有效率高于对照组(P<0.05)。结论联用银杏达莫、黄芪注射液可能通过改善高凝状态、调节免疫力,对PNS的治疗有更好的效果。

Objective To observe the effect of Ginkgo-dipyridamole injection combined with Radix Astragali injection on immune globulin and hypercoagulabale state in primary nephrotic syndrome（mesangial proliferative glomerulonephritis,MSPGN）.Methods Patients with primary nephrotic syndrome were randomly divided into treatment group and control group.On the basis of conventional treatment in both groups,the treatment group was treated by intravenous drip infusing Ginkgo-dipyridamole and Radix Astragali respectively,once a day,and the control group by intravenous drip infusing salvia miltiorrhiza.The changes of the serum PT,APTT,FDP,IgG,IgA,IgM,C3 and C4 were observed before treatment and after 3-month treatment.Results After three-month treatment,the levels of PT and APTT were significantly improved in the treatment group compared with the control group（P0.05）.The FDP level was decreased compared with the control group（P0.05）.The IgG level was improved compared with the control group（P0.05）.Conclusion Ginkgo-dipyridamole combined with Radix Astragali injection has a better therapeutic effect on primary nephrotic syndrome by improving immune globulin and hypercoagulabale state.