血清sLOX-1水平与2型糖尿病合并冠心病的相关性分析

Association between serum sLOX-1 levels and coronary artery disease in patients with type 2 diabetes

目的：评价血清可溶性凝集素样氧化型低密度脂蛋白受体-1（sLOX-1）的水平与2型糖尿病患者合并冠心病（CAD）的相关性。方法：本横断面研究共纳入177名2型糖尿病患者,分为两组：2型糖尿病无冠心病（DM2）组（109例）及2型糖尿病合并冠心病（DM2＋CAD）组（68例）。用酶联免疫吸附法（ELISA）测量每组患者的sLOX-1水平。结果：DM2＋CAD组患者血清sLOX-1水平明显高于DM2组患者[2014（820~3679）pg/ml：1265（527-2047）pg/ml,P〈0.01]。多元Logistic回归分析显示血清sLOX-1水平是2型糖尿病患者存在CAD的独立危险因子（优势比2.477,95%可信区间1.385-4.683;P〈0.05）。结论：血清sLOX-1水平是2型糖尿病患者合并冠心病的独立危险因子,重要预测指标。

Objective：To investigate whether circulating soluble lectin-like oxidized low-density lipoprotein receptor-1（sLOX-1） level is associated with coronary artery disease（CAD） in patients with type 2 diabetes（DM2）.Methods：A total of 177 patients with DM2 were enrolled in this cross-sectional study.The patients were divided into two groups：DM2 group（DM2 without CAD group,n=109） and DM2 with CAD group（DM2＋CAD group,n=68）.Enzyme linked immunosorbent assay（ELISA） was used to measure sLOX-1 level of each group.Results：Serum sLOX-1 level was significantly higher in DM2＋ CAD group than that of DM2 group [2014（820~3679）pg/ml vs.1265（527-2047）pg/ml P〈0.01].Multiple Logistic analysis showed that serum sLOX-1 level was independently associated with CAD in patients with DM2（odds ratio was 2.477,95% confidence interval was 1.385~4.683;P0.05）.Conclusion：Serum sLOX-1 level is independently associated with coronary artery disease in patients with type 2 diabetes.The measurement of serum sLOX-1 level may be potentially useful in predicting the presence of coronary artery disease in patients with type 2 diabetes.