离子液体中1,3,5-三取代六氢均三嗪类化合物的绿色合成

Green Synthesis of 1,3,5-tri-substituted Perhydro-s-triazines in Ionic Liquids

为了实现1,3,5-三取代六氢均三嗪类化合物的绿色合成,制备了咪唑型、吡啶型和三乙胺型多种离子液体,将其应用于有机腈和三聚甲醛的反应,合成了乙酰基-、丙酰基-、丁酰基-和苯甲酰基-1,3,5-三取代六氢均三嗪化合物并进行了表征,优化了工艺条件。结果表明,磺酸功能化Bronsted酸性离子液体活性最高,在最优条件下,1,3,5-三取代六氢均三嗪类化合物收率均大于80%,选择性大于98%。磺酸功能化离子液体能有效提高有机腈和三聚甲醛的反应速率,反应在1h内进行完全,并且重复使用三次活性基本不变。

The green synthesis of three 1,3,5-substituted（acetyl,propionyl and butanoyl） hexahydro-s-triazines was performed in various ionic liquids（ILs）.The effects of the type and addition of IL,reaction temperature and time were investigated and discussed.The IL′s activity and selectivity depend on their acidity.The ideal ILs are sulfuric acid functional ones which could give a yield of target compounds up to 80% at 1 h reaction time.These kinds of ILs have selectivity of higher than 98%,and could be reused for three times without reducing activity.The characterizations of prepared ILs and triazine derivatives have been done with FTIR,1HNMR,MS and elemental analysis.