清瘟败毒饮治疗肾综合征出血热发热期作用机理的探讨

Action mechanism of Qingwen Baidu Decoction in treatment of fever period of hemorrhagic fever with renal syndrome

目的:本实验旨在通过实验室研究进一步探讨清瘟败毒饮治疗肾综合征出血热发热期的作用机理,为清瘟败毒饮治疗肾综合征出血热发热期提供实验依据。方法:应用流式细胞仪检测治疗组和对照组患者淋巴细胞CD4+、CD8+细胞的数量及CD4+/CD8+比值。结果:治疗组与对照组相比,CD4+T淋巴细胞明显增加(P<0.05),CD8+T淋巴细胞数量显著减少(P<0.01),CD4+/CD8+T淋巴细胞比值显著提高(P<0.01)。结论:本实验证实,在治疗肾综合征出血热方面,清瘟败毒饮联合西医疗法明显优于单独使用西医疗法,具有调整机体细胞免疫功能,可以更加明显地改善肾综合征出血热的临床症状。

Objective： To explore the action mechanism of Qingwen Baidu Decoction in treating the fever period of hemorrhagic fever with renal syndrome（HFRS） in an attempt to supply the experiment basis for its treatment.Methods：The flow cytometry was used to detect the lymphocyte CD4＋,CD8＋ and CD4＋/CD8＋ in the two groups.Results：The CD4＋ T lymphocytes were obviously increased（P0.05）and the CD8＋ T lymphocytes were obviously decreased（P0.01）,and the CD4＋ / CD8＋ T was obviously increased in the treatment group compared with the control group（P0.01）.Conclusion：Qingwen Baidu Decoction combined with western medicine is significantly superior to western medicine in the treatment of HFRS and the former shows its effects of the regulation of cell immune function and the improvement of the HFRS symptoms.