乙酰水杨酸合成方法改进

Improved Synthesis of Acetylsalicylic Acid

以水杨酸和乙酸酐为原料,以弱酸硫酸铝钾作催化剂可以方便的合成乙酰水杨酸,实验结果表明:反应温度、反应时间、催化剂用量、水杨酸与乙酸酐的比例等因素均有影响,最佳反应条件是:催化剂的用量为0.6g,n(水杨酸)n(乙酸酐)=1.0 2.0,恒温70℃,反应时间为30min,在优化的反应条件下,乙酰水杨酸的产率为77.8%。结果还表明,硫酸铝钾作为催化剂产率高于浓硫酸作催化剂的产率,而且产品色泽为白色,且纯度高。

With salicylic acid and acetic anhydride as raw material,and potassium aluminum sulfate to weak acid as a catalyst,the acetylsalicylic acid can be synthesized easily.The experimental results show that：the reaction temperature,reaction time,catalyst amount,the ratio of salicylic acid,acetic anhydride and other factors are influential to that.The best reaction conditions are：0.6g catalyst,n（acid）：n（acetic anhydride）= 1.0：2.0,constant temperature at 70 degrees,30min reaction time,with optimal reaction conditions,the acetyl acid production rate was 77.8%.The results also show that the production rate is higher with the aluminum potassium sulfate as a catalyst than that with concentrated sulfuric acid as catalyst,and product color is white,and with high purity.