摘要
室温下以N-(5-溴-2-羟基苄基)氨基酸及其希夫碱为配体,水和甲醇为溶剂,采用分步法,将配体与金属离子按1:1的摩尔比在弱碱性条件下络合,合成了24种N-(5-溴-2-羟基苄基)氨基酸类金属配合物,并用核磁、红外光谱对其结构进行了表征.结果表明:在配合物中配体N-(5-溴-2-羟基苄基)氨基酸的羟基、氨基和羧基均参与了配位.抑菌测试表明,N-(5-溴-2-羟基苄基)氨基酸衍生物金属配合物的抑菌活性普遍高于其配体,并且还原型配合物活性要高于希夫碱型,对白色念珠菌的抑菌效果更为明显,均高达100%.
In recent years,amino acids metal complexes have gotten lots of attention.In order to find more stable and effective antibacterial compounds,we screened some N-(5-Br-2-hydroxybenzyl) amino acid with good antibacterial activity which were synthesized by our team before and essential metal elements to synthesize 24 complexes.These complexes were synthesized in step-by-step method in alkaline solution of water and methanol mixed solvents at room temperature,and the molar ratio of ligands and metal ion was 1∶ 1.The structures of the compounds were characterized by 1H NMR、IR.It was shown that the hydroxyl group,amine group and carboxyl group of ligands were coordinated with metal ion.The results of preliminary bioassay showed that almost all the complexes had better anti-bacteria property than their ligands,especially to the Monilia albicans with 100% inhibitory ratio.
出处
《天津理工大学学报》
2010年第6期66-71,共6页
Journal of Tianjin University of Technology
基金
国家自然科学基金(20776114
20976135)
天津市高校科技发展基金(2006ZD33)