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缺血后适应在急性心肌梗死再灌注损伤中的保护作用研究进展

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摘要 在急性心肌梗死缺血心肌再灌注过程中常发生心肌缺血再灌注损伤。临床表现为在闭塞的冠状动脉再通及梗死区血液灌流重建后一段时间内，有的病例发生血压骤降、心功能不全、心律失常甚至猝死等一系列病情恶化的现象。其发生机制主要与氧自由基生成、钙超载和白细胞活化等有关。
作者 潘港 徐细平 晏新民
机构地区 湖南省岳阳市一人民医院
出处 《中国医学创新》 CAS 2010年第36期177-179,共3页 Medical Innovation of China
关键词 缺血后适应 急性心肌梗死 再灌注
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献13

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  • 4Yang XM,Proctor JB,Cui L,et al.Multiple,brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways.Am Coll Cardiol,2004,44(5):1103-1110.
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  • 6Hausenloy DJ,Tsang A,Mocanu MM,et al.Ischemic preconditioning protects by activating prosurvival kinases at reperfusion.Am J Physiol Heart Circ Physiol,2005,288(2):971-976.
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二级参考文献41

  • 1师恩祎,江晓菁,白菡,中岛芳树.吗啡预处理的晚期心肌保护作用及其与诱导型一氧化氮合酶的关系[J].中华医学杂志,2004,84(11):891-895. 被引量：8
  • 2张兴华,李春梅,马晓静,罗曼.肢体与心肌缺血后处理对兔急性心肌缺血再灌注损伤的对比研究[J].中华医学杂志,2006,86(12):841-845. 被引量：29
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  • 5Tsang A,Hausenloy DJ,Mocanu MM,et al.Postconditioning; a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-akt pathway.Circ Res,2004,95:230-232.
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  • 10Chatelain P,Latour JG,Tran D,et al.Neutrophil accumulation in experimental myocardial infarcts:relation with extent of injury and effect of reperfusion.Circulation,1987,75:1083-1090.

共引文献45

中国医学创新
2010年 第36期

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