肿瘤标志物CEA、NSE和CYFRA21-1在肺腺癌术前及术后血清中的表达研究

Clinical significance of the levels of tumor markers (CEA,NSE,CYFRA21-1) in patients with lung adenocarcinoma

目的研究肿瘤标志物在肺腺癌术前及术后的水平变化,探讨其对肺腺癌诊断及预测术后复发的临床意义。方法应用放射免疫法检测经病理确诊的60例肺腺癌术前、术后1周、术后3个月,30例肺部良性病变和40例正常体检者血清中的癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)和细胞角蛋白21-1(CYFRA21-1)的含量。结果肺腺癌组CEA、NSE、CY-FRA21-1测定水平明显高于肺部良性病变组和正常对照组,且术后1周、术后3个月肺腺癌组随时间延长CEA、NSE、CY-FRA21-1水平亦明显下降,3个月后早期复发者其水平亦明显升高。结论 CEA、NSE、CYFRA21-1对肺腺癌的辅助诊断有一定的临床意义,有助于肺腺癌的鉴别诊断和预测复发。

Objective To investigate the significance of changes of tumor markers in patients before and after operation with lung adenocarcinoma,exploring the clinical significance of diagnosing and predicting recurrence of lung adenocarcinoma.Methods Serum CEA,NSE,CYFRA21-1 levels were determined with RIA in 60 patients with lung adenocarcinoma between before and after operation 1 week,3 months,and 30 patients with lung benign diseases as well as 40 healthy peoples.Results The levels of all three tumor markers measured in serum were more higher in lung adenocarcinoma group than that in lung benign disease group and controlgroup,the levels of all three tumor markers were decreasing with time extending,and the levels were higher with reoccuring of lung adenocarcinoma.Conclusion CEA,NSE,CYFRA21-1 are helpful in the auxiliary diagnosis of lung adenocarcinoma,differential diagnosing and recurring of lung adenocarcinoma.