香参软胶囊对溴代苯致肝损伤小鼠肝组织中MDA、GSH-Px的影响

Protective effects of PLO and PssNe soft capsuleson on bromobenene-induced oxidative liver damage in mice

目的:探讨香参软胶囊对溴代苯肝毒性的保护作用和抗氧化作用。方法:小鼠经口摄入受试物30 d后,给予溴代苯致实验性肝损伤,检测肝匀浆中MDA含量、GSH-Px活性,观察香参软胶囊的作用。结果:各剂量组肝匀浆MDA含量均明显低于模型对照组,中、高剂量组能显著提高GSH-Px活性。结论:香参软胶囊能提高肝损伤小鼠的抗氧化能力,该胶囊对溴代苯致急性肝损伤有保护作用。

Objective：To investigate the protective effects of PLO and PssNe soft capsuleson on bromobenene-induced oxidative liver damage in mice.Methods： In this study,the effect of PLO and PssNe soft capsuleson through zoological experiment was studied after consecutive administration by oral gavage for 30 days,liver was sampled to determine the MDA content and GSH-Px activity.Results： It found that PLO and PssNe soft capsuleson could significantly reduce the content of MDA in three different doses,and could significantly improve the GSH-Px activity in 0.21 g/kg BW and 0.41 g/kg BW doses.Conclusion： It indicated that the mice obtained the anti-oxide ability by PLO and PssNe soft capsuleson taken orally.