联合检测血清和胸水中四种肿瘤标记物对肺癌的诊断意义

The clinical significance of combined detection of four tumor markers in serum and pleural fluid in the patients with lung cancer

目的:探讨联合检测血清和胸水中四种肿瘤标记物对肺癌的诊断意义。方法:采用化学发光和电发光法对60例肺非癌病人和52例肺癌病人血清和胸水的癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白片段19(CYFRA21-1)和神经原特异性烯醇化酶(NSE)水平进行检测。结果:肺癌患者胸水中CEA为237.4±209.1 ng/ml,CA125为234.0±154.1 U/ml,NSE为38.4±26.5 ng/ml,CYFRA21-1为64.7±61.8 ng/ml,显著高于本组血清(P<0.01)和非肺癌疾病组的血清和胸水中的水平(P<0.01)。胸水中四项联检对肺癌的敏感性达96.6%,而对应的血清中四项联检对肺癌的敏感性则为92.3%。结论:联合检测血清和胸水中CEA、CA125、NSE和CYFRA21-1对肺癌的诊断具有重要意义。

Objective：To study the diagnostic value of detection of CEA,CA125,CYFRA21-1 and NSE in pleural fluid samples for pleural metastasis of lung cancer.Methods： Immunoprotein quantity of CEA,CA125,CYFRA21-1 and NSE was analyzed in pleural fluid and serum from patients with lung cancer（52 cases） and in pleural fluid from non cancerous patients（60cases） by using Chemiluminescence immunoassay and Electrochemiluminescence immunoassay.Results：The levels of CEA,CA125,CYFRA21-1 and NSE in pleural fluid of patients with lung cancer were significantly high than those of non cancerous patients（P0.01）.The levels of CEA,CA125 CYFRA21-1 and NSE in pleural fluid were obviously higher than those in serum（P0.01）.The sensitivity of detection CEA＋CA125＋CYFRA21-1＋NSE in pleural fluid and serum were 96.6% and 92.3% respectively.Conclusion：Combined detection of CEA,CA125 CYFRA21-1 and NSE in pleural fluid and serum might be helpful for diagnosing pleural metastasis of lung cancer