脂蛋白(a)水平与心血管疾病之间的关系研究

Research on relationship between lipoprotein (a) levels and cardiovascular disease

目的:探讨脂蛋白(a)[Lipoprotein(a),Lp(a)]的致病作用和质量变化与心血管疾病之间的关系。方法:对临床确诊的急性心肌梗死(Acute Myocardial Infarction,AMI)、陈旧性心肌梗死和不稳定性心绞痛患者采用免疫比浊法测定静脉血浆Lp(a)质量变化。结果:Lp(a)的质量在急性、陈旧性心肌梗死和不稳定性心绞痛患者都增高;AMI组与对照组比较差异有显著性意义(P<0.05);不稳定性心绞痛和陈旧性心肌梗死患者与对照组相比,差异无显著性意义(P>0.05);AMI患者经皮冠状动脉介入治疗(Percutaneous Coronary Intervention,PCI)术前Lp(a)质量比术后增高(P<0.05);Lp(a)≥300 mg/L的心血管疾病患者和对照组之间差异有显著性意义(P<0.05);Lp(a)≥300 mg/L导致心血管疾病的相对危险度为1.44倍。结论:Lp(a)的质量不是恒定不变的;其可能是AMI的一种急性时相蛋白;高水平Lp(a)可能是心血管疾病的危险因素;功能性Lp(a)的质量检测方法需要进一步研究。

Objective：To investigate the relationship between the concentration of lipoprotein（a） and cardiovascular disease.Methods： lipoprotein（a） concentrations were detected by immunoturbidimetry in patients with Acute Myocardial Infarction（AMI）,Old Myocardial Infarction and unstable angina.Results： Concentration of Lp（a） in patients with AMI increased（P0.05）;In patients with Unstable angina and old myocardial infarction also increased（P0.05）;Concentration of Lp（a） in patients with acute myocardial infarction increased before PCI surgery（P0.05）;The quantity of Lp（a）≥300 mg/L between Cardiovascular Patients and control group is significant;The risk is increased for 1.44 times in patients with cardiovascular disease when Lp（a）≥300 mg/L.Conclusion： The concentration of Lp（a） is not constant;It may be an acute-phase protein of AMI;High concentration of Lp（a） may be cardiovascular risk factors;Detection method of Lp（a） concentration should be studied.