具有特征香味的丙烯基烷基甲酮合成

Synthesis of Some Propenyl Alkyl Ketone with Characteristic Flavor Properties

利用烷基酯与烯丙基氯进行格氏反应得到烷基二烯丙基甲醇,在碱性条件下对叔醇进行分解,再通过用对甲苯磺酸催化异构得到丙烯基烷基甲酮。此方法可应用于合成含丙烯基酮结构的特征香味料和香料中间体。

This paper reports an efficient three-steps synthesis of propenyl alkyl ketone which involves the fragmentation,in an aprotic solvent,of a dihomallylic potassium alkoxide whose parent alcohol is readily prepared from a carboxylic ester by the double addition of allyl magnesium chloride through Grignard reaction,then the mixture obtained by the fragmentation can further be treated by p-toluenesulfonic acid.The described method is fit for the synthesis of characteristic flavoring substances and intermediates with propenyl alkyl ketone structure.