我院抗菌药物使用与大肠埃希菌耐药水平变化的关系

Relationship between Consumption of Antibiotics in Our Hospital and Variation of Drug Resistance Level of Escherichia Coli

目的探讨抗菌药物使用量与大肠埃希菌耐药性的关系,为临床合理应用抗菌药物提供科学依据。方法统计2004—2008年住院患者抗菌药物使用情况以及大肠埃希菌的药物敏感试验结果,数据用SPSS13.0软件进行多元线性回归,分析大肠埃希菌耐药水平与抗菌药物用量的关系。结果耐药性大肠埃希菌的增多与抗菌药物的消耗量之间存在一定的量化关系。结论临床医师应合理选用抗菌药物,以减少细菌耐药现象。

Objective To investigate the relationship between the consumption amount of antibiotics in our hospital and the drug resistance level of Escherichia coli in order to provide scientific basis for the rational use of antibiotics.Methods The consumption of antibiotics in inpatients in our hospital from 2004 to 2008 and the susceptibility test results on Escherichia coli were investigated,and the data were subjected to be processed by multiple linear regression using SPSS 13.0.Results The quantitative relation was noted between drug resistance of Escherichia coli and the consumption of antibiotics.Conclusion Antibacterial drugs should be used rationally in clinical practice so as to reduce antibiotic resistance.