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艾司西酞普兰合并奎硫平治疗帕金森病伴抑郁27例 被引量：4

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摘要 目的探讨艾司西酞普兰合并奎硫平治疗帕金森病伴抑郁的疗效。方法将54例患者随机分成艾司西酞普兰组(单用组)和艾司西酞普兰合并奎硫平组(合用组),共观察6周,于治疗前及治疗后1,2,4,6周末采用汉密尔顿抑郁量表(HAMD量表)和不良反应量表(TESS量表)评定疗效及不良反应。结果治疗第6周末,合用组疗效显著,显效率为85.19%,与单用组70.37%比较有显著性差异(χ2=4.52,P<0.05);合用组在1周末起效,单用组在2周末起效;两组治疗后1,2,4周末HAMD量表评分有显著性差异(P<0.05),TESS量表评分无明显差异(P>0.05)。结论艾司西酞普兰合并奎硫平治疗帕金森病伴抑郁,疗效显著且起效快、安全性好,值得临床推广。
作者 胡婀娜 兰智勇 胡伟明 郑利锋 张弛
机构地区 浙江省衢州市第三医院
出处 《中国药业》 CAS 2010年第23期77-78,共2页 China Pharmaceuticals
关键词 艾司西酞普兰 奎硫平 帕金森病 抑郁 疗效
分类号 R969.4 [医药卫生—药理学] R971.43 [医药卫生—药品]
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参考文献8

  • 1Liu CY,Wang SJ,fuh JI,et al.The correlation of depression with func tional activity in parkinsons diseas[J].J Neurol,1997,244(8):493 -498.
  • 2Den Oudsten BL,Van Heck GL,De Vries J.Quality of life and related con cepts in Parkinson's disease:A systematic review[J].Mov Disord,2007,22(11):1528-1537.
  • 3Fontaine R,Ontiveros A,Elie R,et al.A double-blind comparison of nefazodone,imipramine,and plancebo in major depression[J].Clin Psychiatry,1994,55 (6):234 -241.
  • 4Ring HA,Wintoson ML,Cilly H,et al.Depression in Parkinson's disease.A positron emission tomography study[J].Br J Psychiatry,1994,165(3):333 -339.
  • 5司天梅,舒良.关于新抗抑郁药艾司西酞普兰[J].临床精神医学杂志,2007,17(1):68-69. 被引量：124
  • 6Murdoch D,Keam SJ.Escitalopram:a review of its use in the management of major depressive disorder[J].Drugs,2005,65(16):2379-2404.
  • 7Gorman JM,Korotzer A,Su G.Efficacy comparison of escitalopram and citalopram in the treatment of major depressive disorder:pooled analysis of placebo -controlled trials[J].CNS Spectr,2002,7(4 suppl 1):40-44.
  • 8Todder D,Caliskan S,Baune BT.Night locomotor activity and quality of sleep in quetiapine-treated patients with depression[J].J Clin psychopharmacol,2006,26 (6):638 -642.

二级参考文献14

  • 1Owens MJ,Knight DL,Nemeroff CB.Second generation SSRIs:human monoamine transporter binding profile of escitalopram and R-fluoxetine[J].Biol Psychiatry,2001,50:345-350.
  • 2Chen FH,Larsen MB,Sanchezc,et al.The S-enantiomer of R,S-citalopram,increases inhibitor binding to the human serotonin transporter by an allosteric mechanism.Comparison with other serotonin transporter inhibitors[J].Eur Neuropsychopharmacology,2005,15:193-198.
  • 3Mork A,Kreilgaard M,Sanchez C.The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats[J].Neuropharmacology,2003,45:167-173.
  • 4Sanchez C.R-citalopram attenuates anxiolytic effects of escitalopram in a rat ultrasonic vocalization model[J].Eur J Pharmacol,2003,464:155-158.
  • 5Sanchez C,Gruca P,Papp M.R-citalopram counteracts the antidepressant-like effect of escitalopram in a rat chronic mild stress model of depression[J].Behav Pharmacol,2003,14:465-470.
  • 6Plenge P,Mellerup ET,Laursen H.Affinity modulation of[^3H]imipramine,[^3H]paroxetine and[^3H]citalopram binding to the 5-HT transporter from brain and platelets[J].Eur J Pharmacol,1991,206:243-250.
  • 7Fava M,Davidson KG.Definition and epidemiology of treatment resistant depression[J].Psychiatr Clin North Am,1996,19:179-200.
  • 8Thase ME.The Concept of Remission:validity and limitations[J].JClin Psychiatry,2006,67:478-481.
  • 9Thase ME.Evaluating antidepressant therapies:Remission as the optimal outcome[J].J Clin Psychiatry,2003,64(Suppl 13):18-25.
  • 10Murdoch D,Keam SJ.Escitalopram:a review of its use in the management of major depressive disorder[J].Drugs,2005,65:2379-2404.

共引文献123

同被引文献19

二级引证文献13

中国药业
2010年 第23期

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