摘要
目的探讨富马酸喹硫平对精神分裂症患者认知功能的影响。方法本研究采用自身对照研究设计。对云南省精神病医院82例符合《中国精神障碍分类与诊断标准》的精神分裂症患者使用富马酸喹硫平治疗8周,于治疗前及治疗后使用阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)、韦氏记忆量表(Wechsler Memory Scale,WMS)和威斯康星卡片分类测验(Wisconsin CardSorting Test,WCST)进行评估,观察富马酸喹硫平对精神分裂症患者认知功能的影响。结果治疗8周后,PANSS总分显著降低(P<0.01);WCST中错误应答数、非持续性错误的分值显著降低(P<0.05);WMS中记忆商(memory quotient,MQ)、再生和理解的分值显著升高(P<0.05)。结论富马酸喹硫平治疗精神分裂症可改善部分患者的认知功能。
Objective To investigate the effects of cognitive function in the treatment with Quetiapine Fumarate of schizophrenia.Methods The study adopted self-control design.82 patients with schizophrenia of the Mental Hospital of Yunnan which accorded with the diagnostic criteria of mental disorders of china took quetiapine fumarate for 8 weeks.PANSS,and WCST were used to evaluate the effects of cognitive function of schizophrenia before and after the treatment.Results After 8 weeks of treatment,the score of PANSS was decreased significantly（P0.01）.The scores of fault answer and undurative fault in WCST decreased significantly（P0.05）.The memory quotient（MQ）,scores of reactive and comprehension in WMS rose significantly（P0.05）.Conclusion Quetiapine Fumarate is effective in the treatment of schizophrenia,and it can improve some patients＇ cognitive function.
出处
《中国实用医药》
2010年第36期3-4,共2页
China Practical Medicine
