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不明原因复发性自然流产胚胎绒毛组织MiRNAs的表达研究 被引量：8

Differential Expression of miRNAs in Villus from URSA Patients
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摘要 利用miRCURY LNATMmicroRNA Arrays 10.0对不明原因复发性自然流产胚胎绒毛和正常胚胎绒毛组织miRNAs进行了检测.结果显示流产绒毛和正常绒毛组织有43个miRNAs存在明显表达差异(ratios≥2.0或ratios≤0.5),其中上调表达33个,下调表达10个.文献检索显示有12个差异表达miRNAs(上调10个,下调2个)已有功能研究报道,主要与细胞侵袭、离子转运和信号转导相关,另外31个尚无功能研究报道.该研究结果提示自然流产绒毛组织中某些差异表达的miRNAs可能与不明原因复发性自然流产的发生有关. The miRCURY LNATM microRNA Arrays 10.0 was used to investigate the miRNA expression profiles in URSA villus and normal villus.Differential expression of 43 miRNAs were detected,including up-regulation of 33 miRNAs and down-regulation of 10 miRNAs.Index by literatures,functions of 12 differential expression miRNAs have been described,involving mainly in cellular invasion,ionic transport and signal transduction while the others were not reported up to the present.It is suggested that some differential expression miRNAs in URSA villus might be a factor responsible for the URSA pathogenisis.
作者 胡建刚 何俊琳 黎刚 刘学庆 丁裕斌 谭彬 王应雄 余秋波
机构地区 重庆医科大学生殖生物学研究室
出处 《西南大学学报（自然科学版）》 CAS CSCD 北大核心 2010年第12期56-62,共7页 Journal of Southwest University(Natural Science Edition)
基金 国家自然科学基金资助项目(30700898) 重庆市科委自然科学基金资助项目(CSTC 2007BB5286)
关键词 复发性自然流产 绒毛 MIRNA recurrent spontaneous abortion villus miRNA
分类号 Q343.1 [生物学—遗传学]
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参考文献15

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二级参考文献34

共引文献20

同被引文献53

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引证文献8

二级引证文献30

西南大学学报（自然科学版）
2010年 第12期

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