紫杉醇联合卡铂治疗Ⅱb期宫颈癌的疗效观察

Effect of combined treatment with paclitaxel and carboplatin on cervical cancer at stage Ⅱb

目的：评价紫杉醇联合卡铂（TP）治疗Ⅱb期宫颈癌的临床疗效。方法：2007年1月~2009年12月经病理确诊的30例Ⅱb期宫颈癌患者,采用TP方案化疗1~2个疗程后行广泛性子宫切除术及盆腔淋巴结清扫术。观察宫颈癌病灶、宫旁组织在化疗前、后的改变,化疗毒副反应以及术后病理情况等。结果：化疗后,完全缓解5例（16.7%）,部分缓解20例（66.7%）,化疗有效率为83.3%（25/30）,且宫颈癌病灶、宫旁组织有不同程度的改善。化疗后25例患者进行了广泛性子宫切除术及盆腔淋巴结清扫术,手术切除率达到83.3%。结论：Ⅱb期宫颈癌术前TP方案化疗后近期疗效显著,手术的切除率得到明显的提高。

Objective：To evaluate the clinical efficacy of combined treatment with paclitaxel and carboplatin on cervical cancer at stage Ⅱb.Methods：From January 2007 to December 2009,a total of 30 cases with cervical cancer at stage Ⅱb were diagnosed by pathological test in our hospital.All 30 patients were treated with combined therapy with paclitaxel and carboplatin for 1 or 2 courses before radical surgery.The change about location of cervical cancer and status of adjacent tissue lesions after chemotherapy,occurrence of adverse reaction and postoperative pathological condition,etc were observed.Results：After chemotherapy,5 cases（16.7%） showed complete remission,20 cases（66.7%）showed partial remission,and the rate of clinical response was 83.3%（25/30）.Adjacent tissue had improvement to different degree.After adjuvant chemotherapy,25（83.3%）cases had extensive radical hysterectomy with pelvic lymphadenectomy.Conclusions：Combined treatment with paclitaxel and carboplatin is effective on patients with cervical cancer at stage Ⅱb before surgery.It can significantly promote clinical efficacy and increase surgical rates.