摘要
目的:观察局灶性脑缺血后非缺血区皮质的扩散性抑制波(SD)。方法:Sprague-Dawley大鼠12只,随机分为光化学诱导组、光化学抑制组、大脑中动脉栓塞(MCAO)诱导组和MCAO抑制组,每组各3只。前2组制备光化学血栓脑缺血模型,后2组制备MCAO脑缺血模型,光化学抑制组和MCAO抑制组分别于造模前给予MK-801抑制SD。采用电生理学方法记录非缺血区(枕叶皮质)细胞外直流电位变化。结果:光化学诱导组和MCAO诱导组记录到幅度约10～30mV,时程约1～2min的SD,光化学抑制组和MCAO抑制组未记录到SD。结论:局灶性脑缺血诱导的SD传播到非缺血区,这一现象可能与局灶性脑缺血模型中远隔损伤的发生有关。
Objective：To observe spreading depression（SD） in the regions far from the ischemia area of focal cerebral ischemia.Methods：SD waves were elicited by photochemical thrombolytic focal cerebral ischemia and middle cerebral artery occlusion（MCAO） induced cerebral ischemia.In the inhibited groups,MK-801 was intraperitoneally pre-injected.Results：SD waves with an amplitude about 10～30 mV and a duration about 1～2 min were recorded in the induced groups and no SD wave was detected in the inhibited groups.Conclusion：SD waves induced by focal cerebral ischemia can propagate to remote regions.SD may play a part in the remote effects after focal cerebral ischemia.
出处
《神经损伤与功能重建》
2011年第1期11-14,共4页
Neural Injury and Functional Reconstruction
关键词
局灶性脑缺血
扩散性抑制波
光化学血栓
大脑中动脉栓塞
focal cerebral ischemia
spreading depression
photochemical thrombosis
middle cerebral artery occlusion
