冠脉造影对糖尿病患者胱抑素C和肾功能的影响

Effects of Coronary Angiography on Cystatin C and Renal Function in Patients with Diabetes

目的:观察冠脉造影对糖尿病患者胱抑素C(CysC)和肾功能的影响,探讨造影剂肾病(CIN)发生的危险因素及其防治方法。方法:选取在我院行冠状动脉造影术患者78例,分为糖尿病组42例,对照组36例,于造影术前及术后第1,2,7天检测血清胱抑素C和肾功能。结果:糖尿病患者造影术后1d血CysC明显升高,与术前相比有统计学意义(P<0.05)。78例患者中发生CIN10例,其中糖尿病组8例,发生率为19.0%,对照组2例,发生率为5.6%。结论:冠脉造影可引起一过性肾损害,糖尿病是冠脉造影的危险因素。

Objective： To study the effect of coronary angiography on Cystatin C and renal function in patients with diabetes, and to explore the risk factors and prevention methods methods of contrast induced nephropathy （CIN）. Methods： A total of 78 patients, who had been successfully carried on coronary angiography, were divided into diabetes group （n=42） and control group （n=36）. Cystatin C and renal function were detected before and 1, 2, 7 days after coronary angiography. Results： Cystatin C increased significantly in diabetic patients one day after angiography than in normal control patients （P0.05）. Ten of 78 patients suffered from CIN including 8 diabetic patients and 2 control patients. Conclusion： Coronary angiography can cause a momentary renal damage, and diabetes is one of risk factors for coronary angiography.