期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

GPC-3异常表达、信号通路及肝癌的靶向治疗 被引量：6

Abnormal expression of glypican-3,signal pathways and targeted-therapy for he patocellular carcinoma
下载PDF
导出
摘要 磷脂酰肌醇蛋白多糖-3(glypican-3,GPC-3)在肝癌(HCC)发生中介导多种信号通路,对活化途径进行干预,可抑制HCC发生;它具有癌胚胎性蛋白特性,有望成为肝癌靶向治疗的目标。 Glypican-3（GPC-3） mediated oncogenesis is involved into signal pathways during the malignant transformation of hepatocyte carcinogenesis,and GPC-3 may inhibit the formation of hepatocellular carcinoma（HCC）.It is a promising targeted-molecule for HCC therapy.
作者 卞银珠 姚登福
机构地区 南通大学附属医院临床医学研究中心
出处 《胃肠病学和肝病学杂志》 CAS 2011年第1期11-14,共4页 Chinese Journal of Gastroenterology and Hepatology
基金 江苏省卫生科技项目(H2009025)
关键词 肝细胞癌 磷脂酰肌醇蛋白多糖-3 信号通路 靶向治疗 Hepatocellular carcinoma Glypican-3 Signal pathways Targetedtherapy
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献3

二级参考文献13

  • 1Zhi-Zhen Dong,Deng-Fu Yao,Deng-Bing Yao,Xin-Hua Wu,Wei Wu,Li-Wei Qiu,Dao-Rong Jiang,Jian-Hua Zhu,Xian-Yong Meng.Expression and alteration of insulin-like growth factor II-messenger RNA in hepatoma tissues and peripheral blood of patients with hepatocellular carcinoma[J].World Journal of Gastroenterology,2005,11(30):4655-4660. 被引量：45
  • 2Peto J. Cancer epidemiology in the last century and the next decade [J], Nature, 2001, 411(6835): 390 -395.
  • 3Thorgcirsson SS, Grisham JW. Molecular pathogcncsis of human hepatocellular carcinoma[J]. Nat Genet, 2002, 31(4): 339-346.
  • 4Scharf JG, Dombrowski F, Ramadori G. The IGF axis and hepato-carcinogenesis[J]. Mol Pathol, 2001, 54(3): 138-144.
  • 5Flanders KC, Burmester JK. Medical applications of transforming growth factor-beta[J]. Clin Med Res, 2003, 1 ( 1 ) : 13-20.
  • 6Kang-Park S, Lee JH, Shin JH, et al. Activation of the IGF-II gene by HBV-X protein requires PKC and p44/p42 map kinase signalings[ J ]. Biochem Biophys Res Commun, 2001, 283(2) : 303-307.
  • 7Arsura M, Panta GR, Bilyeu JD, et al. Transient activation of NF- kappa B through a TAKI/ IKK kinase pathway by TGF-betal inhibits AP-1/SMAD signaling and apoptosis : implications in liver tumor formation[J]. Oncogene, 2003, 22(3): 412-425.
  • 8Chan DW, Ng IO. Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma ceils [ J ]. J Pathol, 2006, 208(3) : 372-380.
  • 9Zhang X, Zhang H, Ye L. Effects of hepatitis B virus X protein on the development of liver cancer[ J ]. J Lab Clin Med, 2006, 147 ( 1 ) : 58- 66.
  • 10Pan J, Clayton M, Feitelson MA. Hepatitis B virus X antigen promotes transforming growth factor-betal (TGF-beta1) activity by up-regulation of TGF-betal and down-regulation of alpha2-macroglobulin [ J ]. J Gen Virol, 2004, 85 ( Pt 2 ) : 275-282.

共引文献49

同被引文献73

引证文献6

二级引证文献11

胃肠病学和肝病学杂志
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部