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Glypican-3与原发性肝癌的关系研究进展 被引量:1

Relationship between Glypican-3 and hepatocellular carcinoma
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摘要 近年来有关Glypican-3(GPC3)与原发性肝癌(HCC)关系的研究逐年增多,发现GPC3无论在原发性肝癌病人的血清中还是肿瘤组织中均有较高的表达,对原发性肝癌的诊断具有较高的灵敏性和特异性。其表达水平与原发性肝癌的预后也有一定的关系。同时,GPC3也为原发性肝癌的治疗带来了新的思路。 In recent years,the study about the relationship between Glypican-3(GPC3) and hepatocellular carcinoma(HCC) increased year by year.GPC3 has higher expression in the blood serum and tumor tissues of patients with HCC,and it has higher sensitivity and specificity in the diagnosis of HCC.The expression of GPC-3 also has a certain relationship with the prognosis of HCC.Meanwhile,GPC3 provided a novel for the treatment of HCC.
出处 《胃肠病学和肝病学杂志》 CAS 2011年第1期15-17,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 GPC 原发性肝癌 诊断 治疗 预后 GPC3 Hepatocellular carcinoma Diagnosis Treatment Prognosis
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  • 1Shirakawa H, Suzuki H, Shimomura M, et al. Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma [ J ]. Cancer Sci, 2009, 100(8): 1403-1407.
  • 2Filmus J, Capurro M, Rast J. Glypicans [ J]. Genome Biol, 2008, 9 (5) : 224.
  • 3Oliver F, Chriistians JK, Rhind S, et al. Regulatory variation at glipican-3 underlies a major QTL in mice [ J ]. Plos Biol, 2005, 3 (5) : 135.
  • 4Buchanan C, Stigliano I, Garay-Malpartida HM, et al. Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways [ J]. Breast Cancer Res Treat, 2010, 119(3) : 559-574.
  • 5Song HH, Shi W, Xinag YY. The loss of glypican-3 induces alterations in Wnt signaling [J]. Biol Chem, 2005, 280(3): 2116-2125.
  • 6Capurro MI, Xiang YY, Lobe C, et al. Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling [J]. CancerRes, 2005,65(14): 6245-6254.
  • 7Wang FH, Yip YC, Zhang M, et al. Diagnostic utility of glypican-3 for hepatocellular carcinoma on liver needle biopsy [ J ]. Clin Pathol, 2010, 63(7) : 599-603.
  • 8Capurro MI, Shi W, Sandal S. Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth [J]. Biol Chem, 2005, 280(50): 41201-41206.
  • 9Hippo Y, Watanabe K, Watanabe A, et al. Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for earlystage hepatocellular carcinoma [ J ]. Cancer Res, 2004, 64 (7) : 2418- 2423.
  • 10Nakatsura T, Nishimura Y. Usefulness of the novel oncofetal antigen glypican-3 for diagnosis of hepatocellular carcinoma and melanoma [ J ]. Bio Drugs, 2005, 19(2): 71-77.

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