血浆同型半胱氨酸和血清叶酸水平与结直肠腺瘤性息肉相关性研究

Association of plasma homocysteine,serum folic acid and adenomatous polyps of colon and rectum

目的了解结直肠腺瘤性息肉患者的血浆同型半胱氨酸和血清叶酸水平,并探讨之间的关系。方法选取42例结直肠腺瘤性息肉患者和46例健康对照者,测定其血浆同型半胱氨酸水平及血清叶酸水平。结果结直肠腺瘤性息肉患者的血浆同型半胱氨酸水平显著高于健康对照者(15.04μmol/L±4.80μmol/Lvs8.23μmol/L±3.70μmol/L,P<0.001),血清叶酸水平显著低于健康对照者(4.46 ng/mL±3.63 ng/mLvs13.65 ng/mL±4.86 ng/mL,P<0.001)。结论结直肠腺瘤性息肉与血浆同型半胱氨酸水平升高和血清叶酸水平降低之间存在一定联系,可能是结直肠腺瘤性息肉的危险因素,有必要对此作进一步的探讨。

Objective To identify the relationship of plasma homocysleine and serum folic acid in patients with adenomatous polyps of colon and rectum. Methods Forty-two patients with adenomatous polyps of colon and rectum and 46 healthy controls were studied.Plasma homocysteine and serum folic acid levels were determined in blood samples. Results In patients with adenomatous polyps of colon and rectum,the plasma level of homocysleine was significantly higher than that in the heanlthy controls（15.04 μmol/L ±4.80 μmol/L vs 8.23 μmol/L ±3.70 μmol/L,P0.001）,and the serum level of folic acid was markedly lower than that in the healthy controls（4.46 ng/mL±3.63 ng/mL vs 13.65 ng/mL ±4.86 ng/mL,P0.001）. Conclusion Adenomatous polyps of colon and rectum may be correlated with increased plasma homocysteine and decreased serum folic acid levels.Increased plasma homocysteine and decreased serum folic acid levels may be the risk factors for adenomatous polyps of colon and rectum.