高敏C反应蛋白、肿瘤坏死因子-α在2型糖尿病与牙周病关系中的作用

Serum high sensitivity C-reactive protein and tumor necrosis factor-α levels in type 2 diabetes mellitus and periodontal diseases

目的:探讨高敏C反应蛋白和肿瘤坏死因子-α在2型糖尿病与牙周病关系中的作用。方法:随机选取健康体检者(A组)、单纯2型糖尿病患者(B组)和2型糖尿病合并牙周病患者(C组)各20例,分别测定空腹血糖、空腹胰岛素、游离脂肪酸、糖化血红蛋白、高敏C反应蛋白和肿瘤坏死因子-α水平,并进行分析。结果:C组空腹血糖、空腹胰岛素、游离脂肪酸、糖化血红蛋白、高敏C反应蛋白和肿瘤坏死因子-α水平、胰岛素抵抗指数均高于A,B组(P均<0.05),B组高于A组(P<0.05);B,C组胰岛素抵抗指数与空腹血糖、空腹胰岛素、游离脂肪酸、糖化血红蛋白、高敏C反应蛋白、肿瘤坏死因子-α明显相关,其中C组更明显(P均<0.01)。结论:2型糖尿病患者合并牙周病时,高敏C反应蛋白、肿瘤坏死因子-α水平显著升高,将加重糖尿病和牙周病病变。

Objective To investigate the role of serum high sensitivity C-reactive protein and tumor necrosis factor-α levels in type 2 diabetes and periodontal diseases.Methods Twenty healthy controls（group A）,20 patients with type 2 diabetes mellitus（group B）,20 patients with type 2 diabetes mellitus and periodontal disease（group C） were determined and analyzed the levels of fasting plasma glucose,fasting insulin,glycosylated hemoglobin,free fatty acid,high sensitivity C-reactive protein and tumor necrosis factor-α.Results The levels of fasting plasma glucose,fasting insulin,glycosylated hemoglobin,free fatty acid,high sensitivity C-reactive protein and tumor necrosis factor-α were higher in group C than those in group A and B（P0.05）.The insulin resistance index was obviously correlated to the levels of high sensitivity C-reactive protein and tumor necrosis factor-α in group B and C,especially in group C（P0.01）.Conclusion The levels of high sensitivity C-reactive protein and tumor necrosis factor-α are elevated,and may aggravate the diabetes mellitus and periodontal disease.