促红细胞生成素及其受体在直肠癌中表达及临床意义

Expression and clinical significance of erythropoietin and erythropoietin receptor in rectal cancer

目的:探讨促红细胞生成素(erythropoietin,EPO)及促红细胞生成素受体(erythropoietin receptor,EPOR)在直肠癌中的表达情况及临床意义。方法:应用免疫组织化学方法检测60份直肠癌组织标本及60份正常直肠组织标本EPO与EPOR的表达情况。结果:(1)EPO和EPOR在正常直肠组织中的高表达率均为0,在直肠癌组织中的高表达率分别为65.0%、80.0%,差异有统计学意义(P<0.05)。(2)高、中分化腺癌中EPO及EPOR高表达率分别为40.6%、65.6%,低分化腺癌及未分化癌中高表达率分别为92.8%、96.4%,差异均有统计学意义(P<0.05)。Dukes分期A期和B期中EPO及EPOR高表达率分别为35.7%、64.3%,C期高表达率分别为90.6%、93.8%,差异均有统计学意义(P<0.05)。(3)EPO与EPOR在直肠癌组织中表达的相关分析结果显示EPO与EPOR呈正相关(r=0.419,P=0.004)。结论:直肠癌组织中EPO和EPOR的高表达水平与预后不良有关;EPO和EPOR共同促进直肠癌的发展、侵袭和转移。

Objective To investigate the expression of erythropoietin and erythropoietin receptor in rectal cancer and analyze its clinical significance.Methods Immunohistochemistry technique was used to detect the expressions of erythropoietin and erythropoietin receptor in 60 cases of rectal cancer and 60 cases of normal rectal tissues.Results（1） The expression rates of erythropoietin and erythropoietin receptor were 0 in normal rectal tissues and 65.0% and 80.0% in rectal cancer tissues respectively,which showed significant differences between two groups（P0.05）.（2）The high expression rates of erythropoietin and erythropoietin receptor were 40.6% and 65.6% in highly and moderately differentiated adenocarcinoma,and were 92.8% and 96.4% in poorly differentiated adenocarcinoma and undifferentiated carcinoma respectively,which showed significant differences between two groups（P0.05）.The high expression rates of erythropoietin and erythropoietin receptor was 35.7% and 64.3% in Dukes stage A and B,and 90.6% and 93.8% in stage C respectively,which showed significant differences（P0.05）.（3）The correlation analysis of erythropoietin and erythropoietin receptor expression in rectal cancer showed that erythropoietin and was positively correlated with erythropoietin receptor（r=0.419,P=0.004）.Conclusion The expression levels of erythropoietin and erythropoietin receptor of rectal cancer tissues are correlated with the poor prognosis.Erythropoietin and erythropoietin receptor can regulate the progression,invasion and metastasis of rectal cancer together.