原发性肺癌患者血清内皮抑素含量检测及其临床意义

Expression and significance of serum endostatin in patients with primary lung cancer

目的分析原发性肺癌患者血清内皮抑素含量与肿瘤临床病理特征及预后的关系。方法 ELISA法检测57例原发性肺癌(A组)及27例肺良性病变(B组)患者术前血清内皮抑素含量。结果 A组血清内皮抑素含量为(132.73±31.69)μg/L,显著高于B组的(84.56±15.47)μg/L(P<0.01)。淋巴结及远处转移组内皮抑素含量明显高于未转移组(P<0.05);肺腺癌患者血清内皮抑素水平高于鳞癌、小细胞癌患者;Ⅲ～Ⅳ期患者血清内皮抑素水平高于Ⅰ～Ⅱ期(P<0.01)。结论肺癌患者血清内皮抑素含量显著增高,且与肿瘤组织学类型、分化程度、TNM分期、淋巴结转移相关,是预测肿瘤恶性行为和评估预后的有效指标。

Objective To evaluate the expression of serum endostatin in patients with lung cancer and its relationship with pathophysiological characteristics.Methods Serum endostatin was detected by ELISA in 57 patients with untreated primary lung cancer（group A） and 27 patients with benign pulmonary diseases（group B）.Results The expression of endostatin in serum was higher in group A than that in group B[（132.73±31.69） μg/L vs.（84.56±15.47） μg/L] （P0.01）,which in group A was higher in the patients with lymph node and distant metastasis,stage Ⅲ or Ⅳ or adenocarcinoma than that without metastasis,stageⅠorⅡ,or squamous cell carcinoma and small cell lung carcinoma（P0.01）.Conclusion The serum expression of endostat is higher in lung cancer than that in benign pulmonary diseases,which is closely associated with TNM stage,lymph node metastasis and clinicopatholgical variables and can be taken as an useful maeker for evaluating the behavior and prognosis of lung cancer.