摘要
肝片吸虫是传播极为广泛的家畜体内寄生虫。文献报道N(2,4,5三氯)苯基2羟基3,5,6三氯苯磺酰胺(简称为HBSA)及其卤化衍生物是比较好的治疗肝片吸虫病药物,部分化合物已获美国专利[1]。经我们近几年对苯磺酰苯胺类化合物药物作用机理的研究初步证实:该类化合物是线粒体氧化...
The substituted 2 hydroxylbenzenesulfonanilides compounds have been synthesized.The decoupling action of these compounds for oxidative phosphorylation in rat liver mitochondria were studied.Decoupling activities were measured by measuring stimulation of state 4 respiration and measuring the increase of Pi in reaction medium.
出处
《化学研究与应用》
CAS
CSCD
1999年第4期422-424,共3页
Chemical Research and Application
关键词
抗肝片吸虫病药
合成
杀虫剂
苯磺酰胺
解偶联
parasite fasciola hepatica,substituted 2 hydroxylbenzenesulfo nanilides,syntheses,uncoupling,fasciolicidal activity
