短暂性脑缺血发作患者肝细胞生长因子水平与颈动脉狭窄的关系研究

The Study on the Relation between Serum Hepatocyte Growth Factor and Carotid Stenosis in Patients with Transient Ischemic Attack

目的探讨短暂性脑缺血发作(TIA)患者血清肝细胞生长因子(HGF)水平与颈动脉狭窄程度的关系。方法选择TIA患者64例和28例健康对照者,采用数字减影血管造影(DSA)判断TIA患者颈动脉狭窄程度,分为颈动脉轻度、中度和重度狭窄组,测定3组患者的血清HGF水平并进行比较。结果各狭窄组患者血清HGF水平均显著高于正常对照组(P<0.01),重度狭窄组患者的血清HGF水平高于中度狭窄组(P<0.05),中度狭窄组患者的血清HGF水平高于轻度狭窄组(P<0.05)。结论血清HGF水平与颈动脉狭窄程度相关,可作为判断早期动脉粥样硬化性病变的指标。

Objective To study the relationship between serum hepatocyte growth factor（HGF） and carotid stenosis in transient ischemic attack patients（TIA）.Methods 64 patients with transient ischemic attack（TIA） and 28 healthy control volunteers were selected in the study.Digital substrction angiography（DSA） was performed on 64 TIA patients to detect carotid stenosis.The patients were divided into three groups based on the level of carotid stenosis：slight stenosis group,mild stenosis group and severe stenosis group.The serum HGF of different groups were tested and compared.Results The levels of serum HGF in each patients′ group were significantly higher than normal healthy control group（P〈0.01）.And its level of the severe stenosis group was significantly higher than that of the mild stenosis group and slight stenosis group（P〈0.01）,and mild stenosis group significantly higher than slight stenosis group（P〈0.05）.Conclusion The levels of serum HGF is highly correlated with the severity of carotid stenosis,and it can be regarded as the index of early atherosclerosis.