二茂钛二甘氨酸盐酸盐的体外抗肿瘤活性及其与DNA的作用研究

In Vitro Antitumor Activity of Titanocene Glycine Complex and Its Interaction with DNA

研究了二茂钛二甘氨酸盐酸盐的体外抗肿瘤活性， 发现该化合物对艾氏腹水癌肿瘤细胞具有很高的活性． 又通过琼脂糖凝胶电泳技术研究了该化合物与ＰＢＲ３２２ ＤＮＡ 的作用， 发现它与ＰＢＲ３２２ ＤＮＡ之间不存在任何插入键合作用， 而且也不会引起ＤＮＡ 链的缺刻．

Titanocene glycine complex, Cp 2Ti(O 2CCH 2NH 3 +Cl -) 2, was found to have in vitro antitumor activity against Ethrlich ascites tumor cells. The interaction between Cp 2Ti(O 2CCH 2NH 3 +Cl -) 2 and DNA was investigated by agarose gel electrophoresis. The results suggested that no intercalation bonding exists between the compound and DNA, and the compound does not induce nicking of DNA.