成都市崇州不明原因骨关节病临床表现

Clinical Manifestation and Diagnosis of Unknown Etiology Osteoarthritic Disease in Chongzhou,Sichuan

目的了解崇州不明原因骨关节病临床表现。方法 对病区和非病区共314人以及部分迁出病区的人群进行详细的流行病学调查、体格检查、运动功能评定、实验室检查及X线拍片检查。结果病区狭小,边缘明显,疾病呈点状分布。疾病主要表现为双侧髋关节和膝关节疼痛,晚期出现关节运动功能障碍而导致跛行。发病有一定家庭聚集性。随年龄增高发病增加;女性高于男性;儿童期发病后不影响成年后身高;单侧发病常见,左侧多于右侧。临床主要诊断为骨关节炎(OA)和髋关节发育不良(DDH),OA的患病率接近全国其他地区,但是病区明显高于对照表。DDH患病率高于其他地区。结论崇州不明原因骨关节病临床表现类似DDH和OA,且DDH患病率明显高于其他地区,OA患病率病区高于对照。

Objective To understand the clinical manifestation and clinical diagnosis of unknown etiology osteoarthritis disease in Chongzhou in Sichuan province.Methods The epidemiology survey,physical examination,functional movement assessment,laboratory test and X-ray examination were conducted among 314 villagers in osteoarthritis disease endemic area and non endemic area,and among the people came from endemic area.Results The endemic area was small with obvious edge.Main manifestation of osteoarthritis disease was fixed bilateral pain of knee joint or hip joint.the disease would lead to a limp due to the joint functional disorders at late stage.The disease appeared familial clustering,and the prevalence increased with age.More females were affected than males.The onset of the disease in childhood would not influence the body growth in the following years.The clinical diagnosis is developmental dysplasia of the hip（DDH） and osteoarthritis（OA）.Conclusion The unknown etiology osteoarthritis disease in Chongzhou in Sichuan was clinically diagnosed as developmental dysplasia of the hip（DDH） and osteoarthritis（OA）.