65岁以上老年乳腺癌临床病理特点分析

ANALYSIS OF CLINICOPATHOLOGIC CHARACTERISTICS OF BREAST CANCER OF OVER 65 YEARS OLD WOMEN

目的探讨65岁以上老年乳腺癌的临床病理特点。方法对株洲市一医院病理科116例65岁以上的老年乳腺癌患者资料进行回顾性分析。分析老年乳腺癌肿块大小、组织学分级、淋巴结转移情况、雌激素受体(ER)、孕酮受体(PR)表达及人表皮生长因子受体2(C-erbB-2)、p53、谷胱甘肽S转移酶π(GSTπ)表达的特点,并与同期115例非老年患者比较。结果①老年乳腺癌肿块大小与非老年组比较,差异无统计学意义(P>0.05)。②老年组与非老年组乳腺癌淋巴结转移率比较差异有统计学意义(P<0.05)。③老年组与非老年组乳腺癌ER、PR、C-erbB-2的表达差异有统计学意义(P<0.05)。老年组ER、PR阳性表达率高,C-erbB-2阴性表达率高。老年组与非老年组乳腺癌p53、GSTπ的表达差异无统计学意义(P>0.05)。④非老年组Ⅲ级(组织学分级)患者比例高于老年组,老年组Ⅰ级患者比例高于非老年组。二组比较差异有统计学意义(P<0.05)。结论老年乳腺癌患者腋窝淋巴结转移率较低,组织学分级较低,ER、PR阳性表达率高,C-erbB-2阴性表达率高。

Objective To study the clinicopathologic characteristics of breast cancer in old women over 65 years old.Methods The clinical and pathological data of 116 cases with breast cancer in the department of pathology in the first Zhuzhou hospital were reviewed retrospectively.The clinicopathologic characteristics of old women with breast cancer were analyzed,including tumor size,lymph node status,histological classification,expression of ER,PR,C-erbB-2,p53,GSTπ et al.And we compared the differences between elder patients（116）and the non-elder group（115）.Results There was no significant difference in tumor size,expression of p53 and GSTπ between the elder group and non-elder group（P0.05）.But in elder group,Lymph node metastasis rate,expression levels of ER.PR and C-erbB-2 were higher than that in non-elder group（P0.05）.Compared with the non-elder group,the positive rates of ER、PR and negative rates of C-erbB-2 in elder group were increased,the proportion of patients with stage I was high and with stage III was low in elder group,which difference was significant（P0.05）.Conclusion With the lower Lymph node metastasis rate and histological classification,there are higher positive rates of ER,PR and negative rates of C-erbB-2 in elder group.