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新烟碱类杀虫剂的选择毒性机理 被引量：6

Mechanisms for selective action of neonicotinoid insecticides
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摘要 新烟碱类杀虫剂在哺乳动物与昆虫之间表现出良好的选择性.从新烟碱类杀虫剂结构与活性的关系、分子特性以及其与烟碱型乙酰胆碱受体的结合部位和亚结合部位的选择性阐释了其选择性机理. Neonicotinoid insecticides exhibit high selective toxicity between mammals and insects.The mechanisms for selective action of neonicotinoid insecticides based on the structure-activity relationships,molecular feature of neonicotinoids,and its binding site and subsite specificity on nicotine acetylcholine receptors were expounded.
作者 邓天福 高扬帆 陈锡岭
机构地区 河南科技学院
出处 《河南科技学院学报》 2010年第4期23-26,共4页 Journal of Henan Institute of Science and Technology(Natural Science Edition)
基金 国家粮食丰产工程资助项目(2004BA520A06-11)
关键词 新烟碱类杀虫剂 烟碱型乙酰胆碱受体 选择毒性 机理 neonicotinoids insecticide nicotine acetylcholine receptors selective action mechanisms
分类号 S481.1 [农业科学—农药学]
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参考文献17

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  • 2Kollmeyer W D,Flattum R F,Foster J P,et al.Discovery of the nitromethylene heterocycle insecticides[M].Tokyo:Yamamoto I,Casida J E.Nicotinoid Iusecticides and the Nicotinic Acetylcholine Receptor,1999:71-89.
  • 3Tomizawa M,Lee D L,Casida J E.Neonicotinoid insecticides:molecular features conferring selectivity for iusect versus mammalian nicotinic receptors[J].Journal of Agricultural and Food Chemistry,2000,48(12):6016-6024.
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二级参考文献57

  • 1Kollmeyer W D, Flattum R F, Foster J P, et al, Discovery of the nitromethylene hetorocycle insecticides [A]. Yamamoto I,Casida J E. Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor [M]. Tokyo: Springer-Verlag,1999.71-89.
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  • 4TANG Zhen-hua (唐振华), BI Qiang (毕强). Molecular Behavior of Insecticide Action (杀虫剂作用的分子行为)[M]. Shanghai(上海): Far-east Publishing Hause (远东出版社),2003.37-422.
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  • 8Matsuda K, Shimomura M, lhara M, et al. Neonicotinoids show selective and diverse actions on their nicotinic receptor targets:electrophysiology, molecular biology, and receptor, modeling studies[J]. Biosci Biotechnol Biochem ,2005,69: 1442-1452.
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  • 10Zhang N, Tomizawa M, Casida J E. α-Nitroketone as an electrophile and nucleophile: synthesis of 3-substituted 2-nitromethylenetetrahydrothiophene and -tetrahydrofuran as Drosophila nicotinic receptor probes [J]. J Agric Food Chem,2004,45: 276-281.

共引文献35

同被引文献60

引证文献6

二级引证文献43

河南科技学院学报
2010年 第4期

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