摘要
目的比较度洛西汀和西酞普兰治疗老年抑郁症的疗效及安全性。方法将69例老年抑郁症患者随机分为度洛西汀组和西酞普兰组，疗程均为6周。采用汉密尔顿抑郁量表（HAMD）和治疗中出现的症状量表（TESS）在治疗前及治疗1、3、6、12周评定疗效和不良反应。结果两组治疗后各时段HAMD评分均较治疗前明显下降（均P〈0．01），两组疗效比较差异无统计学意义（P〉0．05），两组不良反应比较无显著性差异（P〉0．05）。结论度洛西汀是一种安全有效的抗抑郁药，可用于老年抑郁症患者。
Objective To compare the efficacy and safety of Duloxetine and SSRIs in the treatment of senile depression. Methods 69 patients with senile depression were randomly divided into Duloxetine group and SSRIs group for 6 week treatment. Hamilton depression scale （HAMD） and treatment emergent symptom scale （TESS） were used to evaluate the clinical efficacy and safety, before treatment and 1, 3, 6, 12 week alter treatment. Results The score of HAMD reduced significantly after every treatmenttime in two groups （both P 〈 0.01 ）. There were no significant differences in the efficacy and adverse events between the two groups. Conclusion Duloxetine is an effective and safe antidepressant in the treatment of senile depression.
出处
《中外医学研究》
2010年第30期4-6,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
