精明丹冲剂治疗老年及老年前期高脂血症临床观察

A Single-blind, Positive controlled Trial of Jingmingdan Granule As a Treatment for Presenile and Senile Patients with Hyperlipidemia and/or Hyperlipoproteinemia

单盲对照试验观察精明丹冲剂治疗老年及老年前期高脂血症的疗效和安全性。 88例患者被随机分为精明丹冲剂观察组和月见草油胶丸对照组。结果显示 ,观察组胆固醇 (TC)、甘油三酯(TG)、低密度脂蛋白胆固醇 (LDL c)水平较治疗前均非常显著地降低 ,其中TG含量比给药前下降达 61 5 %。同时 ,高密度脂蛋白胆固醇 (HDL c)水平显著增高 ,动脉硬化指数 (AS)也显著下降。治疗显效率为 79 5 5 % ,总有效率为 10 0 % ,其中老年前期的治疗显效率高于老年期。服药后未见毒副反应 ,且对肝功能异常者反有显著降低谷丙转氨酶的效果。部分病例 1年后随访无复发。提示精明丹冲剂益气活血、利水化痰 。

The efficacy and safety of Jingmingdan granule as a treatment for the presenile and senile patients with hyperlipidemia and/or hyperlipoproteinemia was investigated in a single blind study. Patients were randomly assigned to treatment with observation group ( n =44, 12g/bag, tid) and control group ( n =44, 1 g/capsule, bid) for 4 weeks. The primary efficacy measures were the total cholesterol in plasma (TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), total glyceride (TG). After treatment, TC, LDL, and TG were sig_ nificantly gone down in the observation group compared with them before treatment and were significanty different from the control group. Among them TG's reduction was the most significant, reaching 61.50%. HDL was also significantly increased. At the same time arteriosclerostic indexes were significantly reduced, compared with them before treatment. The apparent efficacy of the observation group is 79.55%, much better than the control group, and the apparent efficacy of the presenile group (46～59 year old) higher than senile group (60～79 year old). Side effect was not found in the observation. In contrast, Jingmingdan granule was significantly protective against liver dysfunction in the patients. These data suggest that Jingmingdan granule is a well tolerated drug which can reduce TC, TG and LDL and increase HDL. It also has a protective effect on liver function in patients with hyperlipidemia or hyperlipoproteinemia.