沙参对正常小鼠免疫功能影响的实验研究

Experimental Research of Shashen on Mouse Immunological Function

观察中药沙参的水煎剂、醇沉液、多糖对正常小鼠免疫功能的影响。结果表明 :10 0 %水煎剂对巨噬细胞 (MΦ)吞噬功能、血清溶菌酶水平、迟发超敏反应 (DTH)有非常显著的促进作用 ;对B细胞增殖也有显著促进作用 ,但对T细胞增殖有非常显著抑制作用。 10 %水煎剂对MΦ吞噬功能、DTH有非常显著促进作用。 2 0 %醇沉液对B细胞增殖有非常显著抑制作用。 5 %醇沉液对MΦ吞噬功能、血清溶菌酶水平、DTH有非常显著的促进作用 ,对血清抗体水平有显著的促进作用 ;对B细胞增殖有非常显著的抑制作用。 2 0 %多糖对MΦ吞噬功能有非常显著促进作用 ;对血清抗体水平有显著促进作用 ;对T、B细胞增殖能力均有非常显著抑制作用。 5 %多糖对MΦ吞噬功能有显著促进作用 ,对B细胞增殖有非常显著抑制作用。提示沙参的水煎剂、醇沉液。

Observe effects of the water decoction, alcohol deposit fluid, and polysaccharide of Shashen (Adenophora Root) on immunological function of normal mouse. The results: 100% water decoction had a remarkalbe promotion on the MΦ phagocytosis, serum lysozyme level, delayed hypersensitivity (DTH), and proliferation of B lymphocyte, while an inhibition on T lymphocyte proliferation. The effects of 10% water decoction were similar. 20% alcohol deposit fluid had a markedly inhibition on proliferation of B lymphocyte, but 5% alcohol deposit fluid can inhibit it when obviously improve the phagocytosis, serum lysozyme level, DTH and serum antibody level. 20% polysaccharide had an obvious promotion on MΦ phagocytosis and serum antibody level, while an inhibition on T and B lymphocyte proliferation. 5% polysaccharide had a promotion on MΦ phagocytosis and an inhibition on B lymphocyte proliferation. All indicated that the water decoction, alcohol deposit fluid, and polysaccharide of Shashen could adjust the mouse immunological function.