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干扰素-γ通过Fas/FasL诱导MCF-7乳腺癌细胞凋亡的实验研究 被引量：2

Experimental study on apoptosis of MCF-7 breast cancer cells induced by Interferon-γ through the Fas/FasL
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摘要 目的:研究探讨干扰素-γ(Interferon-γ,IFN-γ)通过Fas/FasL诱导MCF-7乳腺癌细胞凋亡。方法:通过流式细胞技术(FCM)检测干扰素-γ作用后的细胞凋亡情况及Fas、FasL表达情况。结果:MCF-7乳腺癌细胞经干扰素-γ作用后凋亡细胞百分率增加,FasL表达与对照组相比也增加,差异有统计学意义(P<0.05),Fas表达无明显变化,差异无统计学意义(P>0.05)。结论:干扰素-γ可通过Fas/FasL诱导MCF-7乳腺癌细胞凋亡。 Objective：To investigate the mechanism of apoptosis of MCF-7 treated by interferon-γ.Methods：Detected the apoptosis of control group and experimental groups by flow cytometry（FCM）.Results：The percentage of apoptotic cells increased after treated by interferon-γ（P0.05）,and the FasL of percentage of MCF-7 cells increased treated by interferon-γ（P0.05）.Conclusion：Interferon-γ can induced apoptosis of MCF-7 breast cancer cells through the Fas/FasL.
作者 王志学 石利涛 杨宗伟 李汝泓 李春辉 孙立新
机构地区 承德医学院附属医院
出处 《中国当代医药》 2010年第36期5-6,共2页 China Modern Medicine
关键词 IFN-Γ MCF-7 细胞凋亡 FAS/FASL IFN-γ MCF-7 Apoptosis Fas/FasL
分类号 R-33 [医药卫生]
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共引文献15

同被引文献27

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中国当代医药
2010年 第36期

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