G5振动排痰仪联合沙丁胺醇雾化吸入对COPD急性加重期临床效果观察

Observation on clinical effect of G5 vibration sputum instrument combined with inhalation salbutamol in patients with acute exacerbation of chronic obstructive pulmonary disease

目的:研究G5振动排痰仪联合沙丁胺醇雾化吸入对慢性阻塞性肺疾病急性加重期排痰的临床效果。方法:COPD急性加重期患者120例,均符合中华医学会呼吸学会2007年制定的COPD诊断标准。将患者随机分为3组,A组40例,B组40例,C组40例,入选患者均给予氧疗、抗感染、纠正酸碱失衡和电解质紊乱,A组在此基础上采用G5振动排痰仪(美国通用医学物理治疗设备公司生产的G5振动排痰机)治疗,选择频率为15～30Hz,每次15min,3次/d。B组在此基础上采用沙丁胺醇雾化治疗,将沙丁胺醇雾化液5mg用0.9%NaCl溶液稀释成5ml溶液加入德国PARI(百瑞)雾化吸入器内吸入,雾化时间为20min,3次/d,5d为1个疗程。C组采用沙丁胺醇雾化联合振动排痰仪治疗,雾化后间隔30min应用振动排痰仪治疗,3次/d。结果:C组与A组和B组患者的排痰量比较差异有统计学意义(P<0.05)。A组和B组患者的排痰量比较差异无统计学意义。结论:沙丁胺醇雾化吸入联合G5振动排痰仪对慢性阻塞性肺疾病急性加重期排痰效果明显,是治疗慢性阻塞性肺疾病急性加重期的优先选择。

Objective：To study the effect of G5 vibration expectoration instrument combined with inhalation salbutamol in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods：120 patients with AECOPD were randomly divided into three groups,40 patients with AECOPD in Group A were given G5 vibration expectoration for 15 min three times every day.In group B 5 mg salbutamol was diluted to 5 ml with 0.9% sodium chloride solution for nebulization for 20 min three times every day,5-day a course.Group C were treated with inhalation salbutamol combined with G5 vibration expectoration instrument,three times every day,stop 30 min after inhalation.Results：The different of the daily sputum volume has statistical significance（P0.05） between Group C compared with Group A or Group B,there was no significance between Group A compared with Group B of the daily sputum volume.Conclusion：The results indicate the evident effect of G5 vibration expectoration instrument combined with inhalation salbutamol in patients with AECOPD and it is the priority selection for the treatment of AECOPD.