肾移植患者致敏淋巴细胞检测的临床研究

ClinicalStudy on Detection of Sensitized Lymphocytes FollowingRenal Transplantation

用四甲基偶氮唑盐（ ＭＴＴ） 法，检测了４１ 例肾移植患者移植前后的致敏淋巴细胞，以探讨致敏淋巴细胞与移植受者的早期排斥的关系。结果表明，急性排斥组（１４ 例） 受者术前致敏淋巴细胞ＯＤ 值平均为０ ．５６ ±０ ．２０ ，感染组（５ 例）ＯＤ 值为０ ．５６ ±０ ．２３ ，肾功能稳定组（２２ 例）ＯＤ 值为０ ．３２ ±０ ．０５ 。肾移植术后以上各组ＯＤ 值为０ ．４６ ±０ ．１９ 、０ ．４６ ±０ ．７０ 、０ ．３８ ±０ ．０８ 。急性排斥期应用胸腺嘧啶（ＡＴＧ） 治疗前后致敏淋巴细胞也有很大的变化。结果提示移植前检测和术后跟踪检测移植受者致敏淋巴细胞状态，有助于预测术后移植肾的早期排斥反应，对ＡＴＧ 治疗也有一定的指导意义。

The relationship between sensitized lym phocytes and early rejection of recipient was studied by detecting sensitized lymphocyte of 41 cases before and after renaltransplantation . The results showed that 14 cases out of 41 recipients suffered from acute rejections. Before operation ,the mean OD value of sensitized lym phocyte was 0 .56 ±0 .20 in rejections cases(14 cases) ,0 .56 ±0 .23 in infection cases (5 cases) ,and 0 .32 ±0 .05 in stable renal function cases (22 cases) ;after operation ,the values changed to 0 .64 ±0 .19 ,0 .46 ±0 .07 ,and 0 .38 ±0 .08 respectively .In acute rejection phase ,the above values altered dramatically before and aftertreatment of ATG. The result suggested thatit was helpfulto predict the early rejection following renal transplantation by detecting the status of recipients sensitized ly mphocytes preoperatively and postoperatively .It was also guidable for the treatment of ATG.