食管贲门癌伴高血压术后非特异性降压效应的临床分析

Clinical Analysis of Non-specific Antihypertensive Effect after Theoperation of Esophago-Cardiac Cancer by Hypertension

目的探讨食管贲门癌伴高血压术后发生非特异性降压效应的原因和机制。方法舒张压＞14．7kpa或收缩压＞24kpa，术前口服降压药物，术中静滴硝酸甘油控制降压。结果本组58例，术后1-15天，舒张压≤12．6kpa，收缩压下降12％－18％，且血压下降与术前血压呈正相关。结论食管贲门癌伴高血压术后发生非特异性降压效应的原因和机制可能与下列四点有关；（1）应激原解除，应激反应消失。（2）贫血和血液粘滞度降低。（3）胸胃刺激主动脉弓和心肺感受器使减压反射活动增强。（4）手术引起舒血管物质分泌增多和缩血管物质分泌减少。

To study the reason and mechanism of nonsecific antihypertensive effect after the operation of esophago-cardiac Cancer by hypertension. Methods Diastolic pressure(Dp) was higher than 14. 7kpa or systolic pressare (SP) was higher than 24kpa thay reciped antihyperten sive Drugs before the operation or thay were intravanous dripped Nitrogly-Cerinurn. during the operation for deliberate hypotension. Results There were 58 cases in this group after the opemtion. DP was lowered below 12. 6kpa. SP was lowered 12% - 18%.The effect were lowered in asaseiation with blood prassure of fore-operation. Conclusion The following four were reason and mechanism of non-specific antihpertensive effect after the operation of esophago-cnrdiac cancer by hpertensicn: ①thay were done weay with stressor and stress resspones. ② anenia lead to hlood wiscosity lowered. ③ intiapulmonary-stomach stimulused aortic arch and heart lung baroreceptor so antihypertensive reflex increased. ④the secrine of vasedilator matter increased and the secrine of varonstrictor matter decrsed .