三倍量国产钆喷替酸葡甲胺增强MRI探查脑转移瘤的研究

Investigation on detection of brain metastases with triple dose China made Gd DTPA

目的 评价３ 倍量（０－３ ｍｍｏｌ／ｋｇ）国产钆喷替酸葡甲胺（ＧｄＤＴＰＡ）增强ＭＲＩ探查脑转移瘤的效果。方法 用国产ＧｄＤＴＰＡ３ 倍量增强ＭＲＩ检查５５ 例怀疑脑转移瘤的患者。对ＭＲ扫描所见进行定性、定量分析。结果 ３ 倍量增强比常规量增强扫描发现了更多的转移病灶，分别为３７ 及１７５个。对３ 倍量增强扫描多发现的１３８ 个病灶的定量分析表明，３ 倍量增强使病灶的相对信号强度明显增高。尤其值得指出的是，２ 例患者常规量检查正常而３ 倍量增强发现有颅内转移。３ 例患者常规量检查为单发转移而３ 倍量增强发现为多发转移。结论 国产ＧｄＤＴＰＡ３ 倍量（０－３ ｍｍｏｌ／ｋｇ） 增强ＭＲＩ与常规量（０－１ ｍｍｏｌ／ｋｇ）增强ＭＲＩ比较，可提高病灶检出率，并提供更多的诊断信息。

Objective To assess the effectiveness of triple dose China made Gd DTPA in the MR evaluation of patients with brain metastases Methods 55 patients with clinical suspicion of brain metastases were studied prospectively with China made Gd DTPA MR findings were analyzed qualitatively and quantitatively Results 28 patients were proved to have metastases A significantly greater number of lesions was seen on triple dose as opposed to the standard dose images (37/175) Quantitative analysis of the 138 lesions demonstrated only in triple dose contrast images showed increase in relative signal intensity when compared with standard dose studies 2 patients with negative finding with standard dose had lesions identified on triple dose study 3 patients with solitary lesion on standard dose examination demonstrated multiple metastases on triple Conclusions Triple dose (0 3 mmol/kg) contrast study provides improved lesion detectability and additional diagnostic information over the study performed in the same patients with conventional dose (0 1 mmol/kg)