屏气相位对比MRI评价正常人冠状动脉血流储备

Evaluation of coronary flow reserve in normal subjects with breath hold phase contrast magnetic resonance imaging

目的 研究屏气相位对比ＭＲ（ＰＣＭＲ） 技术测定正常人冠状动脉血流储备（ＣＦＲ） 的可行性。方法 健康志愿者１５ 例（男１２ 例，女３ 例）。采用快速屏气Ｋ空间分段ＰＣＭＲ技术，测定冠状动脉左前降支（ＬＡＤ）静息状态和静注潘生丁负荷状态下的舒张期峰值血流速度、容积流率及ＣＦＲ。结果基础状态ＬＡＤ容积流率为（３５－４±１３－３） ｍｌ／ｍｉｎ，静注潘生丁后明显增加至（１５５－４ ±６６－８） ｍｌ／ｍｉｎ（Ｐ＜０－０１）， 平均ＣＦＲ为４－４±０－７３。基础状态ＬＡＤ峰值流速为（２２－５±３－９）ｃｍ ／ｓ， 静注潘生丁后明显增加至（６３－８±１６－７）ｃｍ／ｓ（ Ｐ＜ ０－０１）， 两者比值为２－９±０－７２ 。结论 该研究表明采用屏气ＰＣＭＲＩ流速编码技术可以定量测定正常人冠状动脉容积流率、峰值流速，从而评价ＣＦＲ。

Objective To study the feasibility of coronary flow reserve (CFR) measurements in normal subjects with breath hold phase contrast magnetic resonance (PC MR) technique Methods Fifteen healthy volunteers underwent on 1 5 T scanner MR imaging Peak flow velocity, volume flow rate and CFR in the left anterior descending (LAD) artery were measured before and after administration of dipyridamole (0 56 mg/kg) with breath hold PC MRI Results Mean LAD volume flow rates was( 35 4±13 3) ml/min (mean±standard deviation) in the baseline state It increased significantly ( P <0 01) to (155 4±66 8) ml/min after dipyridamole administration The mean CFR was 4 4±0 73 Peak coronary flow velocity in the LAD artery increased significantly ( P <0 01) from (22 5±3 9) cm/s before administration of dipyridamole to (63 8±16 7) cm/s, after administration the ratio was 2 9±0 72 Conclusions Coronary flow velocity, volume flow rates and CFR can be measured quantitatively with the MR techniques Key words Coronary circulation Magnetic resonance imaging