口腔颌面部恶性肿瘤患者唾液癌胚抗原及IgA测定和临床意义

Carcinoembryonic and IgA level in saliva in the patients with tumor in oral and maxillofacial region

检测正常人及口腔颌面部肿瘤患者唾液中癌胚抗原（CEA）和IgA含量，并探讨其临床意义。方法：CEA采用酶联免疫试剂盒，IgA用免疫球蛋白试剂盒（比法法）。结果：恶性肿瘤和正过人比较，CEA和IgA含量都显著增高（P＜0.01），恶性肿瘤和良性肿瘤比较，CEA和IgA含量方显著增高（P＜0．01）。CEA和IgA含量水平与恶性肿瘤分期呈正相关，CEA相关系往r＝0．60（P＜0．01），IgA相关系数r＝0．41（P＜0．05）。结论；口腔便面部恶性肿瘤患者，唾液中CEA、IgA含量显著增高，并与肿瘤分期呈正相关，签提唾液CEA,IgA检测对肿瘤良、恶性鉴别，临床畏助诊断以及恶性肿瘤预后和疗效监测有一定指意义。

To detect the level of carcitients with tumor in oral and maxillofacial region.Methods:CEA was measured with ELISAand IgA with turbuidity method in 59 adult patoents with oral of maxillofacial tumor (28 withbenign and 31 with malignant ) and 40 healthadults.Results:CEA and IgA in the saliva of pa tients with oral and maxillofacial cancer were significantly higher than those in the saliva of patients with benign tumor or of health adults (P<0.01).The positive rate of saliva CEA and IgAwere 61% and 55% respectively in the patients with malignant tumor.CEA and IgA comcentration in saliva were positively correlated with the grade of malignancy.Their correlation coeffiConclusion:CEA and IgA level in saliva may beused as prognostic indicator in early diagnosis of malignant tumors in oral and maxillofacial regions.